Hemoperfusion refers to the removal of endogenous or exogenous pathogenic substances in the blood through an adsorbent device with a broad-spectrum detoxification effect or fixed specific ligands through extracorporeal circulation to achieve the purpose of blood purification. Hemoperfusion is currently mainly limited to adsorption, so it is also called hemosorption.
Hemoperfusion is often combined with methods such as hemodialysis and plasma exchange. For drugs with large molecular weight, fat-soluble and high binding rate to lipoproteins and poor hemodialysis effect, or for poisons of unknown origin, hemoperfusion can remove them due to its strong adsorption.
Hemoperfusion is currently mainly used clinically in:
1. Rescue a variety of critical illnesses, such as drug poisoning, pesticide poisoning, multiple organ failure, etc.;
2. Treat uremia, improve refractory hypertension and skin itching;
3. Treatment of severe hepatitis, hepatic encephalopathy, and hyperbilirubinemia;
4. Treatment of critical illnesses such as sepsis and systemic inflammatory response syndrome;
5. Treatment of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and psoriasis.
After years of hard work, Nankai Hecheng Company has successfully independently developed a variety of hemoperfusion adsorbents, which have the advantages of high specific surface area, strong adsorption performance, good mechanical strength, low organic residue, good blood compatibility, etc., which are suitable for a variety of disease fields.
Product model performance characteristics Applicable diseases
NKX-1 black non-polar macroporous adsorption resin, high specific surface area, large adsorption capacity for small molecule substances (including medicines and pesticides). Various drugs and food poisonings, such as sleeping pills poisoning, etc.
NKX-3 is a brown-black non-polar macroporous adsorption resin with a high specific surface area. There are both micropores and macropores in the pore structure. It has good adsorption performance for small and medium molecular substances. Creatinine adsorption rate> 70%, VB12 adsorption rate> 95%, low resin organic residue, good blood compatibility.
NKX-4 white or light yellow non-polar macroporous adsorption resin, with high specific surface area, both micropores and macropores in the pore structure, for small molecules (creatinine adsorption rate> 70%) and medium molecular substances (such as molecular 10,000 peptides) has good adsorption performance, low resin organic residue, and good blood compatibility. Uremia
NKX-6 light yellow macroporous anionic resin, with large average pore size, good mechanical strength and easy post-processing. Absorption of total bilirubin in plasma> 1.8μmol/ml
NKX-7 is yellowish or white macroporous anionic resin, with high specific surface area and good mechanical strength. The adsorption amount of total bilirubin in plasma>2.0μmol/ml, the adsorption rate>50%~70% Hyperbilirubinemia
NKX-8 is a white macroporous anion resin with large pore volume and average pore size, and easy post-processing. The adsorption amount of total bilirubin in plasma>2.4μmol/ml, the adsorption rate>70%