Since the solid-phase peptide synthesis method was invented in 1963, it has been widely used in the research of biologically active peptides and protein functions, and the research and production of peptide drugs. The basis of the solid-phase synthesis method is the polymer material as the carrier. This material is generally 100-200 mesh or 200-400 mesh smooth spheres. The skeleton is polystyrene with low crosslinking degree, and methyl chloride is introduced into the skeleton. A wide variety of reactive groups such as aminomethyl, aminomethyl, hydroxymethyl, triphenyl, and benzhydrylamino groups. The advantages of the solid-phase synthesis method are that there is no need for cumbersome intermediate separation and detection, and the speed is fast. The parallel synthesis method can synthesize a compound library including thousands of compounds in a short time, which is particularly suitable for the development of western medicine.
The solid-phase synthesis carrier developed by Nankai Hecheng has a complete range of varieties and specifications and has been sold to almost all developed countries in the world. The company has established close ties with well-known peptide synthesis companies in various countries. In addition to providing general carrier resins and some coupling agents to peptide synthesis companies, it also accepts commissions to synthesize some special carriers, such as carriers with amino acids, carriers with special swelling degree or group loading, and carriers with special groups. , Removal of resin, etc.
The varieties and specifications of the main conventional carriers are shown in the table below.
Product name Group structure rules Grid
Crosslinking degree Particle size Group loading
(%) (mesh) (mmol/g)
Merrifield resin －CH2Cl 1, 2 100~200, 200~400 0.5~2.0
Wang resin －CH2-OC6H4-CH2OH 1, 2 100~200, 200~400 0.5~3.0
Benzyl alcohol resin －CH2OH 1, 2 100~200, 200~400 0.5~3.0
Aminomethyl (AM) resin －CH2NH2 1, 2 100~200, 200~400 0.5~3.0
MBHA resin ① 1, 2 100~200, 200~400 0.3~1.5
Triphenylmethyl chloride resin ② 1, 2 100~200, 200~400 0.4~1.6
Rink acid resin ③ 1, 2 100~200, 200~400 0.3~1.2
Rink amide resin ④ 1, 2 100~200, 200~400 0.3~1.0
Rink Amide-MBHA ⑤ 1, 2 100~200, 200~400 0.3~0.8
Sulfonyl chloride resin －SO2Cl 1, 2 100~200, 200~400 1.0~3.0