Immobilized enzyme technology is to immobilize biological enzymes on a solid carrier for enzymatic reactions in solution. Compared with the free enzyme, the immobilized enzyme has the advantages of high stability, convenient recovery, easy separation from the reaction system, repeated use for many times, low cost, etc., and has a very broad development prospect. Nankai Hecheng Company carried out basic research work on immobilized enzyme technology as early as 18 years ago. Our self-developed carrier resin is the first immobilized enzyme carrier to realize industrial production in China. Not only the enzyme activity is equivalent to that of imported products, the strength is significantly higher than that of imported products, and the price is much lower than that of similar imported products. The company now has a variety of different skeleton structures, different groups, etc., which can support a variety of enzymes, with high enzyme activity, good catalytic kinetic performance, high stability in use, and good mechanical strength. It can be used to prepare amoxicillin. , Cephalosporin antibiotics, food, biosensors and other fields.
| Product number | Structural features | The main purpose |
| ES-1 | Hydrophilic, epoxy | Fixation of 6-APA acylase, CPC oxidase & acylase, one-step 7-ACA acylase |
| ES-101 | High porosity, hydrophobicity, epoxy group | Enzymes with larger molecular weight, such as lipase |
| ES-102 | Hydrophobicity, epoxy group | Immobilized penicillin G acylase |
| ES-103 | Hydrophobicity, epoxy group | Immobilization of 6-APA acylase, 7-ADCA acylase, GL-7-ACA acylase, and one-step CPC acylase |
| ESR-1 | Hydrophilic, amino group | Immobilization of CPC oxidase, GL-7-ACA acylase and penicillin acylase to catalyze the synthesis of amoxicillin |
| ESR-2 | Hydrophobicity, amino group | Immobilized lipase |
| ESR-3 | Hydrophobicity, amino group | Immobilization of CPC oxidase and 7-ACA acylase |
| ESQ-1 | Hydrophobicity, amino group | Immobilized GL-7-ACA acylase, which can immobilize larger molecular weight enzymes, such as lipase |
Part of the enzyme immobilized on the carrier of the hydrophobic backbone is adsorbed on the resin. Treatment with glutaraldehyde will also increase its stability. However, use under acidic conditions should be avoided, as the Schiff base bond breaks and the immobilized enzyme is lost.